Strengthening Construction Management in the Rural Rehab Line of Business

The Five Key ObservationsObservation#1: Rural rehab success emanated from positive thinking and persistent implementationObservation #2: Almost every RHRO would benefit from a substantial increase in the per unit funding available, especially in light of the forthcoming HUD HOME requirement to establish written rehab standards in ten subcategories.Observation #3: A smartphone and tablet with 20 to 40 apps is the rehab specialist's Swiss Army knife. They are our, GPS, calculator, spec writer, office lifeline in case of danger, camera, clock, cost estimator calendar and a hundred other single-purpose but very important uses.Observation #4: NeighborWorks® Rural Initiative could provide a clearinghouse for success techniques targeted to rural rehab. Each month it might focus on a specific aspect of rehab management; inspection checklists in January, green specs in February, feasibility checklist in March, contractor qualification questionnaires in April and so on.Observation #5: Even with most components of in-house contractor success formula in place, per the Statistic Research Institute 53% of construction firms go out of business with in the first 4 years. It remains a very risky model that requires significant; funding, staff experience, administrative support and risk tolerance.Three Rehab Production Models And Their AlternativesThis middle section restates the introduction and methodology and offers a detailed review of the Traditional Rehab Specialist, Construction Management Of Subcontractor and the In-House General Contractor production models .for each model the article provides: definition and staffing pattern, design roles and tasks for each major player, benefits and challenges, alternative models and finally recommendations for successful implementationFocus TopicsDuring our interview process, three ideas surfaced that were best served with a mini discussion of the topic rather than being embedded in the already large middle section.The three topics are; software and technology, management of community relations – marketing and quality control, and budget solution

The Ursinus Weekly, January 8, 1962

Former Ursinusite, now Africa expert, to address Forum Wednesday night • Soc. classes hear prejudice speaker • Volunteer U.C. students pitch in at local Catholic boys\u27 protectory • Dr. Pancoast takes oath as mayor of Collegeville • President\u27s report reveals 1961 data, interesting facts • Fifty students attend open meeting; MSGA\u27s Moll airs campus problems • U.C. receives $2000 from Standard Oil • Delaware museum offers five grants • Day students tell Y of difficulties • Bill Scholl named to MAC first team • Eye surgery to be topic of next pre-med meeting • Singers choose Kershner 1962 business manager • Editorial: The right not to participate • Ursinus in the past • The New Lost City Ramblers at Haverford College • All Italian highways lead to Rome, the city of colorful contrasts • Twenty freshmen answer Weekly competition call • Cagers still seek win key; Losing streak at five games • Grapplers crunch Haverford, 31 to 3, in season\u27s opener • Freshman wrestler Fred Powers adds strength in the 157 lb. weight class • Ursinus again to host county science fairhttps://digitalcommons.ursinus.edu/weekly/1308/thumbnail.jp

Influence Of DNA On The Rate Of Porphyrin Metallation

Poly(dG–dC)₂ and poly(dA–dT)₂ have marked influences on the rate of insertion of copper(II) into cationic porphyrins reflecting the interaction mode of the porphyrin with the nucleic acid

Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma

Stimulation of CD40 or Toll-Like Receptors (TLR) has potential for tumor immunotherapy. Combinations of CD40 and TLR stimulation can be synergistic, resulting in even stronger dendritic cell (DC) and CD8+ T cell responses. To evaluate such combinations, established B16F10 melanoma tumors were injected every other day X 5 with plasmid DNA encoding a multimeric, soluble form of CD40L (pSP-D-CD40L) either alone or combined with an agonist for TLR1/2 (Pam3CSK4 ), TLR2/6 (FSL-1 and MALP2), TLR3 (polyinosinic-polycytidylic acid, poly(I:C)), TLR4 ( monophosphoryl lipid A, MPL), TLR7 (imiquimod), or TLR9 (Class B CpG phosphorothioate oligodeoxynucleotide, CpG). When used by itself, pSP-D-CD40L slowed tumor growth and prolonged survival, but did not lead to cure. Of the TLR agonists, CpG and poly(I:C) also slowed tumor growth, and the combination of these two TLR agonists was more effective than either agent alone. The triple combination of intratumoral pSP-D-CD40L + CpG + poly(I:C) markedly slowed tumor growth and prolonged survival. This treatment was associated with a reduction in intratumoral CD11c+ dendritic cells and an influx of CD8+ T cells. Since intratumoral injection of plasmid DNA does not lead to efficient transgene expression, pSP-D-CD40L was also tested with cationic polymers that form DNA-containing nanoparticles which lead to enhanced intratumoral gene expression. Intratumoral injections of pSP-D-CD40L-containing nanoparticles formed from polyethylenimine (PEI) or C32 (a novel biodegradable poly(B-amino esters) polymer) in combination with CpG + poly(I:C) had dramatic antitumor effects and frequently cured mice of B16F10 tumors. These data confirm and extend previous reports that CD40 and TLR agonists are synergistic and demonstrate that this combination of immunostimulants can significantly suppress tumor growth in mice. In addition, the enhanced effectiveness of nanoparticle formulations of DNA encoding immunostimulatory molecules such as multimeric, soluble CD40L supports the further study of this technology for tumor immunotherapy

Exile Vol. V No. 2

EDITORIAL 4-6 Jamais (poem) by Iris Carroll 6 The Minister\u27s Narcissus by Julia Santucci 7-18 DRAWING by Anne Irgens 12 Solitude (poem) by Christine Condit 18 Island Lady\u27s Bill-Green Sky (poem) by Robert Wehling 19 Looking for Enchantment (poem) by Dennis Trudell 19 Silence (woodcut) by Carol Wilson 20 Saturday Night (story) by Ed Grimm 21-25 On Unemployment (poem) by William Bennett 25 Atlas (poem) by Bob Canary 26 A Psychology of Confrontation (essay) by Barbara Haupt 27-35 Urban (woodcut) by Carol Wilson 36 The Way They Make Guys (story) by Dennis Trudell 37-38 This story [ The Minister\u27s Narcissus ] by Julia Santucci has been awarded the semi-annual EXILE-Denison Bookstore creative writing prize. (pg 18

Characterization of a genomic signature of pregnancy identified in the breast.

The objective of this study was to comprehensively compare the genomic profiles in the breast of parous and nulliparous postmenopausal women to identify genes that permanently change their expression following pregnancy. The study was designed as a two-phase approach. In the discovery phase, we compared breast genomic profiles of 37 parous with 18 nulliparous postmenopausal women. In the validation phase, confirmation of the genomic patterns observed in the discovery phase was sought in an independent set of 30 parous and 22 nulliparous postmenopausal women. RNA was hybridized to Affymetrix HG_U133 Plus 2.0 oligonucleotide arrays containing probes to 54,675 transcripts, scanned and the images analyzed using Affymetrix GCOS software. Surrogate variable analysis, logistic regression, and significance analysis of microarrays were used to identify statistically significant differences in expression of genes. The false discovery rate (FDR) approach was used to control for multiple comparisons. We found that 208 genes (305 probe sets) were differentially expressed between parous and nulliparous women in both discovery and validation phases of the study at an FDR of 10% and with at least a 1.25-fold change. These genes are involved in regulation of transcription, centrosome organization, RNA splicing, cell-cycle control, adhesion, and differentiation. The results provide initial evidence that full-term pregnancy induces long-term genomic changes in the breast. The genomic signature of pregnancy could be used as an intermediate marker to assess potential chemopreventive interventions with hormones mimicking the effects of pregnancy for prevention of breast cancer

Characterization of a genomic signature of pregnancy identified in the breast.

The objective of this study was to comprehensively compare the genomic profiles in the breast of parous and nulliparous postmenopausal women to identify genes that permanently change their expression following pregnancy. The study was designed as a two-phase approach. In the discovery phase, we compared breast genomic profiles of 37 parous with 18 nulliparous postmenopausal women. In the validation phase, confirmation of the genomic patterns observed in the discovery phase was sought in an independent set of 30 parous and 22 nulliparous postmenopausal women. RNA was hybridized to Affymetrix HG_U133 Plus 2.0 oligonucleotide arrays containing probes to 54,675 transcripts, scanned and the images analyzed using Affymetrix GCOS software. Surrogate variable analysis, logistic regression, and significance analysis of microarrays were used to identify statistically significant differences in expression of genes. The false discovery rate (FDR) approach was used to control for multiple comparisons. We found that 208 genes (305 probe sets) were differentially expressed between parous and nulliparous women in both discovery and validation phases of the study at an FDR of 10% and with at least a 1.25-fold change. These genes are involved in regulation of transcription, centrosome organization, RNA splicing, cell-cycle control, adhesion, and differentiation. The results provide initial evidence that full-term pregnancy induces long-term genomic changes in the breast. The genomic signature of pregnancy could be used as an intermediate marker to assess potential chemopreventive interventions with hormones mimicking the effects of pregnancy for prevention of breast cancer